Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).
Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.
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Name Catalog # Size CARD8 RA30062 50 ug CARD9 RA30063 50 ug Caspase-12 RA15048 100 ug Caspase-14 RA30061 50 ug Caspase-3 GT15044 100 ug Caspase-3 (C terminal region) RA21011 50 ug Caspase-3 (N terminal region) RA21012 100 ug Caspase-3, active RA15046 50 ug Caspase-7 MO25036 100 ul Caspase-9 GT15045 100 ul Caspase-9 GT15045 50 ul Cathepsin B (Human) GT15046 100 ug Cathepsin B (Mouse) GT15047 100 ug Cathepsin D GT15042 100 ug Cathepsin F MO15096 500 ug Cathepsin G MO20021 100 ul Cathepsin L (Human) GT15048 100 ug Cathepsin L (Mouse) GT15049 100 ug Cathepsin O GT15197 100 ug Cathepsin S GT15198 100 ug Cathepsin V GT15199 100 ug