Product Details
Catalog Number: RA18005
Applications: WB, IHC, FC
Type: Rabbit IgG
Immunogen: KLH coupled synthetic peptide derived from the sequence of human Cox2.
Storage: Do not aliquot. Store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Entrez: 5743
UniProt: P35354
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ul$387.00Add to Cart

Cyclooxygenase (COX), also known as prostaglandin G/H synthase, is a membrane bound enzyme partly responsible for the catalysis of prostanoid synthesis. COX is expressed as at least three different isoforms. COX-1 is constitutively expressed and thought to regulate a number of 'housekeeping' functions such as vascular hemostasis, renal blood flow, and glomerular function. COX-2 expression is tightly regulated and induced by inflammatory mediators such as growth factors, cytokines, and endotoxin. COX-3 appears to be much more strictly regulated spatially and is observed in greatest abundance in cerebral cortex.

Images

COX-2 staining of paraffin-embedded human colon carcinoma.

COX-2 staining of paraffin-embedded human colon carcinoma.

Western blot analysis of extracts from Raw264.7 cells, untreated or LPS-treated (1 μg/ml for 6 h), using Cox2 Antibody.

Western blot analysis of extracts from Raw264.7 cells, untreated or LPS-treated (1 μg/ml for 6 h), using Cox2 Antibody.

Flow cytometric analysis of Raw cells, untreated (blue) or LPS-treated (green), using Cox2 antibody compared to a nonspecific negative control antibody (red).

Flow cytometric analysis of Raw cells, untreated (blue) or LPS-treated (green), using Cox2 antibody compared to a nonspecific negative control antibody (red).