First purified from clam ganglia, FMRFamide (Phe-Met-Arg-Phe-NH2) is expressed in both invertebrates and vertebrates. its has been shown to serve various functions in the mammalian nervous system including inhibition of morphine-induced feeding, behavioral effects when administered intrathecally, and to have amnesic effects in rodents. More recently, FMRFamide has been shown to potentiate proton currents and a suggested mode of action is through modulation of ASIC1 and ASIC 3.
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- Martin E. J. Stegner, Stefan Richter. (2015). Development of the nervous system in Cephalocarida (Crustacea): early neuronal differentiation and successive patterning. Zoomorphology, doi: 10.1007/s00435-014-0248-1
- Suguru Kobayashi, Mariko Hattori, Károly Elekes, Etsuro Ito, Ryota Matsuo. (2010). FMRFamide regulates oscillatory activity of the olfactory center in the slug. European Journal of Neuroscience, doi: 10.1111/j.1460-9568.2010.07399.x
- Florent G. Revel, Michel Saboureau, Paul Pévet, Valérie Simonneaux and Jens D. Mikkelsen. (2008). RFamide-Related Peptide Gene Is a Melatonin-Driven Photoperiodic Gene. Endocrinology, doi: 10.1210/en.2007-0848
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