Product Details
Catalog Number: RA25015
Applications: WB
Type: Rabbit IgG
Immunogen: A synthetic peptide within an internal region [residues 100-200] of the mouse GPI-anchored HDL-binding protein 1 protein. [Swiss-Prot# Q9D1N2].
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse, Rat
Entrez: 57104
UniProt: Q96AD5
Downloads: Datasheet (pdf)
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100 ul$299.00Add to Cart

Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.

Images

Detection of ATGL in human adipose tissue lysate.

Detection of ATGL in human adipose tissue lysate.