Product Details
Catalog Number: RA25031
Applications: WB
Type: Rabbit IgG
Immunogen: C terminal sequence [EMFLPLRSRTVSRQC] of Bcl10.
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Entrez: 8915
UniProt: O95999
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ul$329.00Add to Cart

Bcl-10 (B Cell Lymphoma 10), also known as CIPER, CARMEN, mE10, clap, and c-E10, is a 26-kDa protein containing an amino-terminal Caspase-recruitment Domain (CARD) found in several apoptotic molecules. Bcl-10, together with CARMA1 and MALT1, forms part of a signal transduction pathway that triggers the activation of NFkB and JNK in response to antigen receptor ligation in T and B lymphocytes. Activation of these pathways leads to the activation, differentiation, and proliferation of specific T and B cell subsets. Chromosomal translocations of the genes encoding Bcl-10 and MALT1 contribute to the pathogenic process leading to MALT lymphomas.

Images

Western blot analysis of Bcl-10 transfected 283 cells.

Western blot analysis of Bcl-10 transfected 283 cells.