Product Details
Catalog Number: RA25040
Applications: ICC, WB, IHC
Type: Rabbit IgG
Immunogen: Synthetic peptide (Rat) from the N-terminal extracellular domain conjugated to immunogenic carrier protein.
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: lyophilized
Species Reactivity: Mouse, Rat
Entrez: 6272
UniProt: Q99523
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$385.00Add to Cart

Neurotensin Receptor 3, also known as Sortilin,  is a member of the family of Vps10p-domain receptors, and is found expressed in brain, spinal cord and muscle. NTS3 is expressed during embryogenesis in areas where nerve growth factor (NGF) and its precursor, proNGF, have well-characterized effects.

It is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

Images

NTS3 staining of 1 day-old mouse cortical cell culture. Dilution-1:2000

NTS3 staining of 1 day-old mouse cortical cell culture. Dilution-1:2000

NTS3 staining of rat brain (cortex)-Dilution-1:1000

NTS3 staining of rat brain (cortex)-Dilution-1:1000