Product Details
Catalog Number: RA25043
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: Synthetic peptide corresponding to amino acids near the N-terminus of Human BACE-2.
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 25825
UniProt: Q9Y5Z0
Downloads: Datasheet (pdf)
Product Sizes
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50 ug$365.00Add to Cart

BACE-2 (Memapsin 1) is a membrane-bound aspartic protease that is highly homologous with BACE-1 (Memapsin 2). While BACE1 processes the amyloid precursor protein (APP) at a key step in generating the beta-amyloid peptide and presumably causes Alzheimer's disease (AD), BACE2 has not been demonstrated to be directly involved in APP processing, and its physiological functions remain to be determined. In vivo, BACE-2 is expressed as a precursor protein containing pre-, pro-, protease, transmembrane, and cytosolic domains/peptides.

It is a close homolog of BACE1, a protease known to be an important enzyme involved in the cellular pathways that some believe lead to Alzheimer's disease. The physiological function and role of BACE2 in Alzheimer's disease is unknown. 

Images

BACE-2 staining of heart mouse tissue. Dilution of 10 ug/ml.

BACE-2 staining of heart mouse tissue. Dilution of 10 ug/ml.

Western blot analysis of BACE2 in human (A) and mouse (B) heart tissue lysates. Dilution: 1 ug/ml.

Western blot analysis of BACE2 in human (A) and mouse (B) heart tissue lysates. Dilution: 1 ug/ml.