Product Details
Catalog Number: RA25070
Applications: WB
Type: Rabbit IgG
Immunogen: Synthetic peptide made to an internal portion of the human TLR9 protein (within residues 1050-1100). [Swiss-Prot# Q9NR96]
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Rat, Primate
Entrez: 54106
UniProt: Q9NR96
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$325.00Add to Cart

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses.

TLR9 forms a subfamily along with TLR7 and TLR8 that recognize viral RNA and CpG DNA sequences and are localized in intracellular acidic compartments such as the phagolysosome. Unlike other TLRs which act through adaptor molecules such as TOLLIP, TIRAP, TRIF, and MyD88 to activate various kinases and transcription factors to respond to potential infection, TLR9 is strictly dependent on MyD88.

Images

TLR9 Western Blot on Jurkat whole cell lysate

TLR9 Western Blot on Jurkat whole cell lysate