Product Details
Catalog Number: RA25075
Applications: WB
Type: Rabbit IgG
Immunogen: Bacterially expressed human HIF-3 alpha (N-terminus).
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse
Entrez: 64344
UniProt: Q9Y2N7
Downloads: SDS (pdf)
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$325.00Add to Cart

Hypoxia-inducible factor (HIF) is one of the most important factors in the cellular response to hypoxia, transcriptionally activating genes encoding proteins that mediate adaptive responses to reduced oxygen availability. HIF is a heterodimer consisting of one of three subunits, HIF1 alpha, HIF2 alpha, or HIF3 alpha. HIF target genes play critical roles in metabolism, angiogenesis, cell proliferation and cell survival. HIF3 alpha protein is one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha 3 subunit lacks the transactivation domain found in factors containing either the alpha 1 or alpha 2 subunits. HIF3 alpha may be a marker for tumor growth and angiogenesis.

Images

Western blot analysis of HIF-3 alpha in Jurkat cell.

Western blot analysis of HIF-3 alpha in Jurkat cell.