Product Details
Catalog Number: RA25091
Applications: ICC, WB, FC, IF
Type: Rabbit IgG
Immunogen: A synthetic peptide made to an internal portion of the human cripto protein sequence (between residues 100-150).
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Entrez: 6997
UniProt: P13385
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ul$295.00Add to Cart

Cripto-1 (CR-1), also known as Teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor (EGF)-GFC family and has been implicated in both embryogenesis and carcinogenesis. During early vertebrate development, CR-1 functions as a co-receptor for Nodal, a transforming growth factor b (TGFb) family member, and is essential for mesoderm and endoderm formation and anterior-posterior and left-right axis establishment. In adult tissues, CR-1 is expressed at a low level in all stages of mammary gland development, and expression increases during pregnancy and lactation.

Over-expression of CR-1 in mouse mammary epithelial cells leads to their transformation in vitro, and when injected in mammary glands, CR-1 produces ductal hyperplasias.

Supporting Products
NameCatalog #Size
Cripto1P2509150 ug Blocking Peptide
Images

Immunocytochemistry/Immunofluorescence: Cripto1 antibody was tested in HeLa cells with Dylight 488 (green). Nuclei were counterstained with DAPI (blue) and tubulin was stained with alpha tubulin (red).

Immunocytochemistry/Immunofluorescence: Cripto1 antibody was tested in HeLa cells with Dylight 488 (green). Nuclei were counterstained with DAPI (blue) and tubulin was stained with alpha tubulin (red).

FACS staining of NTERA-2 cells using Cripto1 antibody at a 1:50 dilution detected using Dylight-488 conjugated

FACS staining of NTERA-2 cells using Cripto1 antibody at a 1:50 dilution detected using Dylight-488 conjugated

Western blot analysis of Cripto1 in MDA-MB231 lysates.

Western blot analysis of Cripto1 in MDA-MB231 lysates.