Placental growth factor (PIGF, PLGF or PGF) is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PIGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues. PIGF expression within human atherosclerotic lesions is associated with plaque inflammation and neovascular growth.
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