Product Details
Catalog Number: RA30008
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: Synthetic peptide corresponding to 16 amino acids near the amino-terminus of human BAX.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Downloads: Datasheet (pdf)
Product Sizes
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50 ug$425.00Add to Cart

 BAX (BCL2-associated X Protein) is a 21 kD pro-apoptotic protien known to regulate apoptosis. BAX is found in the cytoplasm, mitochondria, and nucleus and is highly expressed in hematopoietic stem cells, the ovary, and in the lymph node. Bax binds the anti-apoptotic protein Bcl-2 as a heterodimer or forms homodimers. The relative levels of pro-apoptotic proteins such as Bax and anti-apoptotic proteins such as Bcl-2 determines whether cell death will occur following an apoptotic stimulus. Bax accelerates the opening of mitochondrial VDAC altering membrane potential and allowing cytochrome c to pass out of the mitochondria into the cytosol to initiate downstream caspase activation. p53 can transcriptionally activate the BAX gene to induce apoptosis. Bax has been shown to be mutated in some human cancers

Image: BAX staining of Tonsil: Formalin-Fixed Paraffin-Embedded (FFPE).