Matrix Metalloproteases (MMPs) play important roles in many physiological or pathological processes including embryonic development, morphogenesis, reproduction, tissue remodeling, arthritis, cancer and cardiovascular disease.
MMP14 may be an activator of pro gelatinase A and is expressed in fibroblast cells during both wound healing and human cancer progression. MMP14 is expressed in very low levels and may require stimulation with concanavolin A or the phorbol ester TPA to stimulate production of MMP14.
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