WISP3 is a member of the CCN (for CTGF, CYR61), and NOV gene family, which encode cysteine-rich secreted proteins with roles in cell growth and differentiation. WISP3 is likely required for normal postnatal skeletal growth and cartilage homeostasis. WISP3 is predominantly expressed in adult and fetal kidney and adult testis
Defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging.
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