Product Details
Catalog Number: RA30048
Applications: IHC
Type: Rabbit IgG
Dilutions: IHC 1:1000-1:2000
Immunogen: Synthetic-KLH couple peptide from the 3rd extracellular domain of human GPR3
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Entrez: 2827
UniProt: P46089
Downloads: Datasheet (pdf)
Product Sizes
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50 ug$435.00Add to Cart

GPR3, GPR6, and GPR12 make up a family of constitutively active G protein-coupled receptors (GPCRs) that share greater than 50% identity and 65% similarity at the amino acid level and are highly expressed in hippocampus and cortex, regions of the brain . They upregulate cyclic AMP Levels and Promotes Neurite Outgrowth.

GPR3 has been mapped to a chromosomal locus associated with increased risk for Alzheimer’s disease. GPR3 is believed be a factor in accumulation of beta-amyloid (a protein believed to cause the disease).

Images

GPR3 staining of Human Brain tissue (paraffin-embedded).

GPR3 staining of Human Brain tissue (paraffin-embedded).