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| 100 ug | $375.00 | Add to Cart |
The GDNF family members (GDNF, neurturin and persephin) signal through multicomponent receptors that consist of the Ret receptor tyrosine kinase and one of four glycosyl-phosphatidylinositol (GPI)-linked ligand-binding subunits (GFR alpha-1 -4). GFR alpha-1, -2, and -4 are the preferred ligand-binding subunits for GDNF, neurturin and persephin, respectively. The Ret tyrosine-kinase receptor is encoded by the c-ret proto-oncogene. Human and mouse Ret share 83% amino acid sequence homology. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. |
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Product Publications
- Ellen M. Schill, Christina M. Wright, Alisha Jamil, Jonathan M. LaCombe, Randall J. Roper, and Robert O. Heuckeroth (2019). Down syndrome mouse models have an abnormal enteric nervous system. JCI Insight. https://doi.org/10.1172/jci.insight.124510.
- Irene Cheng Lucy Jin Lucy C. Rose Christopher D. Deppmann (2018). Temporally restricted death and the role of p75NTR as a survival receptor in the developing sensory nervous system. Developmental Neurobiology. doi: https://doi.org/10.1002/dneu.22591
- Han Pin Pui and Yumiko Saga. (2017). Gonocytes-to-spermatogonia transition initiates prior to birth in murine testes and it requires FGF signaling. Mechanisms of Development, Volume 144, Part B, Pages 125–139. doi: 10.1016/j.mod.2017.03.002
- Ryo Hotta, Lily Cheng, Hannah K. Graham, Nandor Nagy, Jaime Belkind-Gerson, George Mattheolabakis, Mansoor M. Amiji, Allan M. Goldstein. (2016). Delivery of enteric neural progenitors with 5-HT4 agonist-loaded nanoparticles and thermosensitive hydrogel enhances cell proliferation and differentiation following transplantation in vivo. Biomaterials, doi: 10.1016/j.biomaterials.2016.02.016
- Athanasia Stathopoulou, Dipa Natarajan, Pinelopi Nikolopoulou, Alexandra L. Patmanidi, Zoi Lygerou, Vassilis Pachnis, Stavros Taraviras. (2015). Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis. Developmental Biology, doi: 10.1016/j.ydbio.2015.11.023
- Ellen Merrick Schilla, Jonathan I. Lake, Olga A. Tusheva, Nandor Nagy, Saya K. Bery, Lynne Foster, Marina Avetisyan, Stephen L. Johnson, William F. Stenson, Allan M. Goldstein, Robert O. Heuckeroth. (2015). Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse. Developmental Biology, doi: 10.1016/j.ydbio.2015.09.023
- Marina Avetisyan, Hongtao Wang, Ellen Merrick Schill, Saya Bery, John R. Grider, John A. Hassell, Thaddeus Stappenbeck, and Robert O. Heuckeroth. (2015). Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury. The Journal of Neuroscience, 35(33): 11543-11558; doi: 10.1523/JNEUROSCI.5267-14.2015
- Dario Bonanomi, Onanong Chivatakarn, Ge Bai, Houari Abdesselem, Karen Lettieri, Till Marquardt, Brian A. Pierchala, Samuel L. Pfaff. (2012). Ret Is a Multifunctional Coreceptor that Integrates Diffusible- and Contact-Axon Guidance Signals. Cell, Volume 148, Issue 3, 568-582, doi: 10.1016/j.cell.2012.01.024
- Danny Galleguillos, José A. Fuentealba1, Luis M. Gómez1, Mathias Saver, Andrea Gómez, Kevin Nash, Corinna Burger, Katia Gysling, María E. Andrés. (2010). Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain. Journal of Neurochemistry, Volume 114, Issue 4, pages 1158–1167. doi: 10.1111/j.1471-4159.2010.06841.x
- Ming Fu, Yoshiharu Sato, Ariel Lyons-Warren, Bin Zhang, Maureen A. Kane, Joseph L. Napoli and Robert O. Heuckeroth. (2010). Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation. Development, 137, 631-640. doi: 10.1242/dev.040550
- Gaurav Tyagi, Kay Carnes, Carla Morrow, Natalia V. Kostereva, Gail C. Ekman, Daryl D. Meling, Chris Hostetler, Michael Griswold, Kenneth M. Murphy, Rex A. Hess, Marie-Claude Hofmann and Paul S. Cooke. (2009). Loss of Etv5 Decreases Proliferation and RET Levels in neonatal Mouse Testicular Germ Cells and Causes an Abnormal First Wave of Spermatogenesis. Biology of Reproduction, doi: 10.1095/biolreprod.108.075200
- Thomas W. Gould, Shigenobu Yonemura, Ronald W. Oppenheim, Shiho Ohmori, and Hideki Enomoto. (2008). The Neurotrophic Effects of Glial Cell Line-Derived Neurotrophic Factor on Spinal Motoneurons Are Restricted to Fusimotor Subtypes. The Journal of Neuroscience, 28(9):2131-2146. doi: 10.1523/JNEUROSCI.5185-07.2008
- Edgar R Kramer, Liviu Aron,1 Geert M. J Ramakers, Sabine Seitz, Xiaoxi Zhuang, Klaus Beyer, Marten P Smidt, and Rüdiger Klein. (2007). Absence of Ret Signaling in Mice Causes Progressive and Late Degeneration of the Nigrostriatal System. PLoS Biol., 5(3): e39. doi: 10.1371/journal.pbio.0050039
- Bhupinder P.S. Vohra, William Planer, Jennifer Armon, Ming Fu, Sanjay Jain, and Robert O. Heuckeroth. (2007). Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis. Developmental Dynamics, 236:106–117. doi: 10.1002/dvdy.21028
- Naughton CK, Jain S, Strickland AM, Gupta A, and Mibrandt J. (2006). Glial Cell-Line Derived Neurotrophic Factor-Mediated RET Signaling Regulates Spermatogonial Stem Cell Fate. BIOLOGY OF REPRODUCTION, 74, 314–321. doi: 10.1095/biolreprod.105.047365
- Sanjay Jain, Mario Encinas, Eugene M. Johnson, Jr. and Jeffrey Milbrandt. (2006). Critical and distinct roles for key RET tyrosine docking sites in renal development. GENES & DEVELOPMENT, 20:321-333. doi: 10.1101/gad.1387206
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Ret staining of spermatagonial stem cells
Ret staining of spermatagonial stem cells
Testosterone and Mullerian inhibiting substance (MIS) do not have deleterious effects on enteric nervous system (ENS) precursor proliferation, differentiation, or survival. A-D: Cultured immunoselected embryonic day (E) 12.5 C57BL/6 ENS precursors were grown for 24 hr with or without glial cell line-derived neurotrophic factor (GDNF), testosterone, or MIS
Testosterone and Mullerian inhibiting substance (MIS) do not have deleterious effects on enteric nervous system (ENS) precursor proliferation, differentiation, or survival. A-D: Cultured immunoselected embryonic day (E) 12.5 C57BL/6 ENS precursors were grown for 24 hr with or without glial cell line-derived neurotrophic factor (GDNF), testosterone, or MIS
Western blot analysis of Ret protein levels in protein lysates from SNpc (top) and striatum (bottom) of 3-mo-old control (Retlx/+and DAT-Retlx/+) and DAT-Retlx/lx mutant mice. Immunoblots were reprobed with anti–α-tubulin antibodies as loading controls.
Western blot analysis of Ret protein levels in protein lysates from SNpc (top) and striatum (bottom) of 3-mo-old control (Retlx/+and DAT-Retlx/+) and DAT-Retlx/lx mutant mice. Immunoblots were reprobed with anti–α-tubulin antibodies as loading controls.