Product Details
Catalog Number: GT15004
Applications: ICC, WB, IHC, E
Type: Goat IgG
Immunogen: Recombinant rat GDNF soluble receptor alpha 1 extracellular domain.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

GDNF, Neurturin, Artemin, and Persephin are distant members of the TGF-beta superfamily that function as neurotrophic factors. Their bioactivities are mediated by a receptor complex composed of the non-ligand-binding signaling subunit (c-Ret receptor tyrosine kinase) and one of four ligand binding subunits designated GFR alpha-1 through 4, which are cysteine-rich glycosyl-phosphatidylinositol (GPI)-linked cell surface proteins.

Images
GDNF R1 Alpha staining of mouse sciatic nerve cross section. Tissue stained with GDNF R1 Alpha labeled with Cy3 (red); the antibody Laminin with 488 (green) and counterstained DAPI (Blue).

GDNF R1 Alpha staining of mouse sciatic nerve cross section. Tissue stained with GDNF R1 Alpha labeled with Cy3 (red); the antibody Laminin with 488 (green) and counterstained DAPI (Blue).

GDNF R1 Alpha staining of mouse sciatic nerve cross section. Tissue stained with GDNF R1 Alpha labeled with Cy3 (red); the antibody Laminin with 488 (green) and counterstained DAPI (Blue).

GDNF R1 Alpha staining of mouse sciatic nerve cross section. Tissue stained with GDNF R1 Alpha labeled with Cy3 (red); the antibody Laminin with 488 (green) and counterstained DAPI (Blue).

Ret and GFRA1 are co-expressed in germ cells early in spermatogenesis At P7 RET and GFRA1 co-localize in the same germ cells (yellow membrane staining). Scale bar: 25 μm. DOI:10.1095/biolreprod.105.047365.

Ret and GFRA1 are co-expressed in germ cells early in spermatogenesis At P7 RET and GFRA1 co-localize in the same germ cells (yellow membrane staining). Scale bar: 25 μm. DOI:10.1095/biolreprod.105.047365.