RAGE (receptor for advanced glycation end products) is a multiligand type I transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily. RAGE ligands include advanced glycation end products (AGEs), amyloid-beta (A beta) peptide, HMG-1 (also known as Amphoterin), and several members of the S100 protein superfamily. RAGE has potential involvement in several pathological processes including diabetes, Alzheimer's disease (AD), systemic amyloidosis, and tumor growth. RAGE may also mediate several physiological functions such as neuronal outgrowth, survival, and regeneration, and play a part in pro-inflammatory reactions.
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