Cathepsin D is a lysosomal aspartic protease of the pepsin family. Human Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 1 18), a propeptide (residues 19 64), and a mature chain (residues 65 412). The mature chain can be processed further to the light (residues 65 161) and heavy (residues 169 412) chains. It is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides.
Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer and possibly Alzheimer's disease
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Name Catalog # Caspase-3 GT15044 Caspase-9 GT15045 Cathepsin B (Human) GT15046 Cathepsin B (Mouse) GT15047 Cathepsin L (Human) GT15048 Cathepsin L (Mouse) GT15049 Cathepsin O GT15197 Cathepsin S GT15198 Cathepsin V GT15199 Cathepsin F MO15096 Cathepsin G MO20021 Caspase-7 MO25036 Caspase-3, active RA15046 Caspase-10/b-Flice 2 RA15047 Caspase-12 RA15048 Caspase-14 RA30061 CARD8 RA30062 CARD9 RA30063