Product Details
Catalog Number: GT15042
Applications: WB, IHC, IP
Type: Goat IgG
Immunogen: Recombinant mouse Cathepsin D
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

Cathepsin D is a lysosomal aspartic protease of the pepsin family. Human Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 1 18), a propeptide (residues 19 64), and a mature chain (residues 65 412). The mature chain can be processed further to the light (residues 65 161) and heavy (residues 169 412) chains. It is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides.

Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer and possibly Alzheimer's disease

Images
Cathepsin-D staining in Rat Cortex. Courtesy of Dr. Inga Kadish, University of Alabama-Birmingham

Cathepsin-D staining in Rat Cortex. Courtesy of Dr. Inga Kadish, University of Alabama-Birmingham

Cathepsin-D staining in Rat Cortex. Courtesy of Dr. Inga Kadish, University of Alabama-Birmingham

Cathepsin-D staining in Rat Cortex. Courtesy of Dr. Inga Kadish, University of Alabama-Birmingham