Cathepsin L is a lysosomal cysteine protease expressed in most eukaryotic cells. Cathepsin L is known to hydrolyze a number of proteins, including the proform of urokinase-type plasminogen activator, which is activated by Cathepsin L cleavage. Cathepsin L has also been shown to proteolytically inactivate a1-antitrypsin and secretory leucoprotease inhibitor, two major protease inhibitors of the respiratory tract.
Cathepsin L has been implicated in several pathologic processes, including rheumatoid arthritis, muscular dystrophy, Alzheimers, cancer, myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria
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Name Catalog # Cathepsin D GT15042 Caspase-3 GT15044 Caspase-9 GT15045 Cathepsin B (Human) GT15046 Cathepsin B (Mouse) GT15047 Cathepsin L (Mouse) GT15049 Cathepsin O GT15197 Cathepsin S GT15198 Cathepsin V GT15199 Cathepsin F MO15096 Cathepsin G MO20021 Caspase-7 MO25036 Caspase-3, active RA15046 Caspase-10/b-Flice 2 RA15047 Caspase-12 RA15048 Caspase-14 RA30061 CARD8 RA30062 CARD9 RA30063