Product Details
Catalog Number: GT15112
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: Purified, E. coli-derived, recombinant human alpha-Synuclein (rhSNCA).
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

alpha Synuclein is a member of a family of small, highly conserved proteins, including synuclein-alpha, -beta, and -gamma, and synoretin. These proteins are localized predominantly in the brain, concentrated in presynaptic nerve terminals. Synuclein-alpha is normally a soluble protein. Abnormal synuclein-alpha forms filamentous inclusions (Lewy bodies and Lewy neurites) in several neurodegenerative diseases, including Parkinson's disease (PD), dementia with Lewy bodies, and Alzheimer's disease. It is a major component of intracellular inclusions in sporadic PD. Mutations in the synuclein-alpha gene (A53T and A30P) have been reported in several families with autosomal dominant Parkinsonism.

This antibody detects the alpha isoform of synuclein and  may cross-react with beta-synuclein.

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