Product Details
Catalog Number: GT15116
Applications: ICC, WB, IHC, E
Type: Goat IgG
Dilutions: ICC 10 ug/ml; IHC 10 ug/ml; WB 0.1 - 0.2 ug/ml
Immunogen: Recombinant human Musashi
Storage: Antibody can be aliquotted and stored frozen at -20° C to -70° C in a manual defrost freezer for six months without detectable loss of activity. The antibody can be stored at 2° - 8° C for 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia and Parkinson's. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 other neurodegenerative diseases Alzheimer's disease and Pick disease suggests that it may play a role in the pathogenesis of these neurodegenerative disorders.

Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be an vital role in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection.

Images

Musashi-1 immunoreactivity in paraffin-embedded human intestine sections using goat anti-human Musashi-1 affinity-purified polyclonal antibody (HRP-DAB, brown); counterstained with hematoxylin (blue).

Musashi-1 immunoreactivity in paraffin-embedded human intestine sections using goat anti-human Musashi-1 affinity-purified polyclonal antibody (HRP-DAB, brown); counterstained with hematoxylin (blue).