VR1, also known as TRPV1 (Transient Receptor Potential Vanilloid 1) and capsaicin receptor, is a 115 kDa integral membrane ion channel that has six transmembrane domains and contains intracellular N-and C-termini. It contributes to normal pain and temperature sensation and also has a "sensory-effector" function. By alternative splicing, at least three VR1 isoforms are known. The sequence of residues 4 - 21 of rat VR1 is 78% and 28% identical to that of mouse and human VR1, respectively.
- Product ReviewsProduct arrived promptly and when I expected. Product Name: TRPV1, rabbit - (Cat# RA14113), VR1 (TRPV1), goat - (Cat# GT15129) https://www.neuromics.com/RA14113 and https://www.neuromics.com/GT15129 Organization: Vanderbilt UniversityNolan - Dec 04, 2017 - Rating: 5.0
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- Product Publications
- Xiaoxue Peng, Keith Studholme, Martha P Kanjiya, Jennifer Luk, Diane Bogdan, Matthew W Elmes, Gregory Carbonetti, Simon Tong, Yu-Han Gary Teng, ,Robert C Rizzo, Huilin Li, Dale G Deutsch, Iwao Ojima, Mario J Rebecchi, Michelino Puopolo, Martin Kaczocha. (2017). Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms. Molecular Pain, doi: 10.1177/1744806917697007
- Ki Seok Lee, Youping Zhang, Jamila Asgar, Q-Schick Auh, Man-Kyo Chung, Jin Y. Ro. (2016). Androgen receptor transcriptionally regulates μ-opioid receptor expression in rat trigeminal ganglia. Neuroscience, doi: 10.1016/j.neuroscience.2016.06.023
- Ken Koda, Kana Hyakkoku, Koichi Ogawa, Keiko Takasu, Sunao Imai, Yusuke Sakurai, Masahide Fujita, Hiroko Ono, Miyuki Yamamoto, Isao Fukuda, Shoji Yamane, Atsushi Morita, Toshiyuki Asaki, Toshiyuki Kanemasa, Gaku Sakaguchi, & Yasuhide Morioka. (2016). Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain. Osteoarthritis and Cartilage, doi: 10.1016/j.joca.2016.02.010
- Deborah M. Hegarty, Sam M. Hermes, Tally M. Largent-Milnes, Sue A. Aicher. (2014). Capsaicin-responsive corneal afferents do not contain TRPV1 at their central terminals in trigeminal nucleus caudalis in rats. Journal of Chemical Neuroanatomy. Journal of Chemical Neuroanatomy, Volumes 61–62, Pages 1–12. doi: 10.1016/j.jchemneu.2014.06.006
- Line Pourtau, Amarins Nieske Heeringa, Carole Rovere, Agnes Aubert, Jean-Louis Nahon, Sylvain Miraux, Jan Pieter Konsman. (2014). Increased circulating rather than spinal cytokines accompany chronic pain behaviors in experimental bone cancer and arthritis. Neuroimmunology and Neuroinflammation, doi: 10.4103/2347-8659.143680
- Haijun Zhang, Jessica A. Boyette-Davis, Alyssa K. Kosturakis, Yan Li, Seo-Yeon Yoon, Edgar T. Walters, Patrick M. Dougherty. (2013). Induction of Monocyte Chemoattractant Protein-1 (MCP-1) and Its Receptor CCR2 in Primary Sensory Neurons Contributes to Paclitaxel-Induced Peripheral Neuropathy. The Journal of Pain, doi: 10.1016/j.jpain.2013.03.012
- Andrea M. Harrington, Patrick A. Hughes, Christopher M. Martin Jing Yang, Joel Castro, Nicole J. Isaacs, L. Ashley Blackshaw and Stuart M. Brierley. (2011). A novel role for TRPM8 in visceral afferent function. PAIN, doi: 10.1016/j.pain.2011.01.027
- Hyun Yeong Kim, Kihwan Kim, Hai Ying Li, Gehoon Chunga, Chul-Kyu Park, Joong Soo Kim, Sung Jun Jung, Min Kyung Lee, Dong Kuk Ahn, Se Jin Hwang, Youngnam Kang, Alexander M. Binshtok, Bruce P. Bean, Clifford J. Woolf, Seog Bae Oh. (2010). Selectively targeting pain in the trigeminal system. PAIN, Volume 150, Issue 1, Pages 29-40. doi: 10.1016/j.pain.2010.02.016
- K. Czaja, G.A. Burns, and R.C. Ritter. (2008). Capsaicin-induced neuronal death and proliferation of the primary sensory neurons located in the nodose ganglia of adult rats. Neuroscience, 154(2): 621–630. doi: 10.1016/j.neuroscience.2008.03.055
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