Product Details
Catalog Number: GT15136
Applications: WB, E
Type: Goat IgG
Dilutions: WB 01. - 0.2 ug/ml; E 0.5 - 1.0 ug/ml
Immunogen: NS0-derived rhBACE-1
Storage: Antibody can be aliquotted and stored frozen at -20° C to -70° C in a manual defrost freezer for six months without detectable loss of activity. The antibody can be stored at 2° - 8° C for 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ug$365.00Add to Cart

BACEs (Beta-site APP-Cleaving Enzymes), also named β-secretases, are membrane-bound aspartic proteases of the pepsin family. BACE-1 is the principle beta-secretase responsible for cleavage of amyloid precursor protein (APP) and, therefore, is a potential target for treatment of Alzheimer's disease. BACE-1 is widely expressed and likely has additional functions including the liberation of a membrane-bound sialyltransferase.

It is important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells.

Images

Product Image Unavailable