The neural cell adhesion molecule L1 (NCAM-L1) is an immunoglobulin superfamily adhesion molecule that is critical for neural development. Two alternatively spliced isoforms of NCAM-L1 have been described, the full length isoform expressed exclusively in neurons, and the non-neuronal variant lacking a five residue extracellular sequence and a four residue cytoplasmic sequence that is important in signaling and clathrin-mediated endocytosis
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