S100s are calcium binding proteins and are located in the the cytoplasm and/or nucleus of a variety of cell types. S100B is composed of two beta chains, and is involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Some of the extracellular functions of S100B may be mediated by RAGE (receptor for advancedglycation end products). Blood levels of S100B can be used to monitor the extent of brain injury and malignant melanoma.
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