Product Details
Catalog Number: GT15162
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: NS0-derived, recombinant mouse CAM-related/Down-regulated by Oncogenes (rmCDO) extracellular domain.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse, Rat
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

Mouse CDO is a 190 kDa member of the Ig/FN-type III repeat subfamily of transmembrane proteins. The extracellular region contains five Ig-like domains and three FN-III modules. The molecule forms cis-complexes with itself and the related molecule termed BOC. CDO and BOC have been implicated in the Hedgehog signaling pathway.

CDO has a role in human forebrain development and  Holoprosencephaly (HPE), a common defect of human forebrain development and is associate with HPE is via haploinsufficiency for genes encoding Sonic Hedgehog (SHH) pathway components.
Images
CDO staining of a  cryostat tissue section of embryonic mouse retina (13 d.p.c.) Tissue was stained using goat HRPDAB (brown). and counterstained with hematoxylin (blue).

CDO staining of a cryostat tissue section of embryonic mouse retina (13 d.p.c.) Tissue was stained using goat HRPDAB (brown). and counterstained with hematoxylin (blue).

CDO staining of a  cryostat tissue section of embryonic mouse retina (13 d.p.c.) Tissue was stained using goat HRPDAB (brown). and counterstained with hematoxylin (blue).

CDO staining of a cryostat tissue section of embryonic mouse retina (13 d.p.c.) Tissue was stained using goat HRPDAB (brown). and counterstained with hematoxylin (blue).