Product Details
Catalog Number: GT15171
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: Purified, NS0-derived, recombinant human Jagged1 (rhJagged1) extracellular domain.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

Mammalian Jagged proteins are homologs of the Drosophila Notch ligand, Serrate, and together with Delta-like proteins, constitute ligands for the mammalian Notch proteins. Jagged1 and 2 are 180 kDa and 150 kDa type I transmembrane glycoproteins, respectively, that possess extracellular DSL (delta, serrate, lag-2 consensus sequence) domains necessary for binding to Notch receptors, along with 15-16 calcium-binding EGF-like repeats which modulate the binding affinity. Jagged-Notch signaling specifies cell fate, regulates pattern formation, defines boundaries between different cell types, and modulates cell proliferation and differentiation, especially during hematopoiesis, myogenesis, neurogenesis and development of the vasculature. Since both the ligands and receptors are transmembrane proteins, direct cell-cell interactions are thought to be required for functional Notch signaling.

Images
Jagged1 staining of paraffin-embedded human kidney cancer. HRP-DAB reagents (brown color) were used for the detection and counterstained using hematoxylin (blue).

Jagged1 staining of paraffin-embedded human kidney cancer. HRP-DAB reagents (brown color) were used for the detection and counterstained using hematoxylin (blue).

Jagged1 staining of paraffin-embedded human kidney cancer. HRP-DAB reagents (brown color) were used for the detection and counterstained using hematoxylin (blue).

Jagged1 staining of paraffin-embedded human kidney cancer. HRP-DAB reagents (brown color) were used for the detection and counterstained using hematoxylin (blue).