Product Details
Catalog Number: GT15176
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: Purified, E. coli-derived, recombinant mouse growth differentiation factor 3 (rmGDF-3).
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

The TGFp superfamily of ligands plays key functions in development and disease. In both human and mouse embryonic stem cells, a member of this family, GDF3, is specifically expressed in the pluripotent state. We show that GDF3 is an inhibitor of its own subfamily, blocks classic BMP signaling in multiple contexts, interacts with BMP proteins and is expressed specifically in the node during gastrulation in a pattern consistent with BMP inhibition. Furthermore, we use gain- and reduction-of-function to show that in a species-specific manner, GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell.

GDF-3 is suspected to be expressed in certain forms of cancer. These could include Breast and Testicular Cancer. 

Images
GDF Staining of mouse thymus. Tissue was stained with goat HRP-DAB (brown) and counterstained with Hematoxylin (blue).

GDF Staining of mouse thymus. Tissue was stained with goat HRP-DAB (brown) and counterstained with Hematoxylin (blue).

GDF Staining of mouse thymus. Tissue was stained with goat HRP-DAB (brown) and counterstained with Hematoxylin (blue).

GDF Staining of mouse thymus. Tissue was stained with goat HRP-DAB (brown) and counterstained with Hematoxylin (blue).