This polyclonal anti-TP63 is predicted to recognize all isoforms of TP63, including TAp63, DeltaNp63, TP63α, β, γ, and δ. TP63, also named p63, TP73L, p51, p40 or KET, was originally identified as a p53 family member. It is highly expressed in embryonic ectoderm and in the nuclei of basal regenerative cells of many epithelial tissues in the adult including skin, breast myoepithelium, oral epithelium, prostate and urothelia. The expression of various TP63 isoforms has been suggested to play a role in development, epithelial cell maintenance and tumorigenesis.1 - 3
1. Courtois, S. et al., 2004, Oncogene 23(3):631 - 638.
2. Koster, M.I. and D.R. Roop, 2004, J. Dermatol. Sci. 34(1):3 - 9.
3. Vincek, V. et al., 2003, Anticancer Res. 23(5A):3945 - 3948.
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