The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate.
SOX21 is a member of the B group of the SOX family HMG-box transcription factors. It is a 276 amino acid residue protein that has an N-terminal HMG-box and a C-terminal domain that is required for the SOX21 neurogenesis function. Human and mouse SOX 21 share 99% amino acid sequence identity.
Note: This antibody has been selected for its ability to recognize human SOX21 in IHC, direct ELISAs and western blots. In direct ELISAs and western blots, this antibody shows less than 1% cross-reactivity with rhSOX1, rhSOX2 and rhSOX15.