Product Details
Catalog Number: GT15209
Applications: WB, IHC, E
Type: Goat IgG
Immunogen: Purified, E. coli-derived, recombinant human SRY (sex determining region Y) box 21 (rhSOX21; aa 2 - 276; Accession # NP_808421).
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate.

SOX21 is a member of the B group of the SOX family HMG-box transcription factors. It is a 276 amino acid residue protein that has an N-terminal HMG-box and a C-terminal domain that is required for the SOX21 neurogenesis function. Human and mouse SOX 21 share 99% amino acid sequence identity.

Note: This antibody has been selected for its ability to recognize human SOX21 in IHC, direct ELISAs and western blots.  In direct ELISAs and western blots, this antibody shows less than 1% cross-reactivity with rhSOX1, rhSOX2 and rhSOX15.

Images

Sox21 is expressed in primary glioma cells and the expression is reduced in differentiated cells. Immunofluorescence staining of human primary glioma cells; U-3001 MG at Passage 4. DOI: 10.1002/ijc.25647

Sox21 is expressed in primary glioma cells and the expression is reduced in differentiated cells. Immunofluorescence staining of human primary glioma cells; U-3001 MG at Passage 4. DOI: 10.1002/ijc.25647