The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate.
SOX21 is a member of the B group of the SOX family HMG-box transcription factors. It is a 276 amino acid residue protein that has an N-terminal HMG-box and a C-terminal domain that is required for the SOX21 neurogenesis function. Human and mouse SOX 21 share 99% amino acid sequence identity.
Note: This antibody has been selected for its ability to recognize human SOX21 in IHC, direct ELISAs and western blots. In direct ELISAs and western blots, this antibody shows less than 1% cross-reactivity with rhSOX1, rhSOX2 and rhSOX15.
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- Maria Ferletta,Demet Caglayan ,Liza Mokvist, Yiwen Jiang, Marianne Kastemar, Lene Uhrbom and Bengt Westermark. (2010). Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells. International Journal of Cancer, doi: 10.1002/ijc.25647
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Name Catalog # Size SOX-10 MO47006 100 ug SOX-2/SRY (sex determining region Y)-box 2 MO47038 100 ul SOX1 GT15208 100 ug SOX10 GT15218 100 ug. SOX10 MO15116 100 ug SOX17 GT15094 100 ug SOX2 GT15098 100 ug. SOX2 MO15040 100 ug SOX2 RA25021 100 ul SOX3 GT15119 100 ug SOX6 RA19023 100 ug SOX7 MO15050 100 ug SOX7 MO15050 50 ug SOX9 GT15207 100 ug SRY (Sex Determining Region Y)-Box 11/SOX-11 MO47052 100 ul