Product Details
Catalog Number: GT15231
Applications: ICC, WB
Type: Goat IgG
Immunogen: E. coli derived recombinant human NeuroD1 (Ser154Asp356). Accession # Q13562
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$365.00Add to Cart

NeuroD1 (Neurogenic Differentiation factor 1, also known as BETA2 (beta-cell E-box transactivator 2) is a 40kDa protein, a member of the bHLH family. NeuroD1 is a homolog of the Drosophila atonal gene.

NeuroD1 is widely expressed during development in the mammalian brain and pancreas where it acts as a transcriptional activator, and binds to insulin gene E-box. NeuroD1 has also been reported to be a differentiation factor in neurogenesis. Changes in NeuroD1 gene expression have been linked to diabetes mellitus type II and maturity-onset diabetes of the young type VI. NeuroD1 expression can be induced by glucose in beta cells.

Images

NeuroD1 staining of immersion fixed beta TC-6 mouse beta cell insulinoma cell line at 10 µg/mL for 3 hours at room temperature. Cells were stained using the Fluoro-labeled ™ 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Protocol on Datasheet.

NeuroD1 staining of immersion fixed beta TC-6 mouse beta cell insulinoma cell line at 10 µg/mL for 3 hours at room temperature. Cells were stained using the Fluoro-labeled ™ 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Protocol on Datasheet.