Product Details
Catalog Number: GT15242
Applications: ICC, WB, IHC
Type: Goat IgG
Immunogen: E. coli coliderived recombinant human ZIC1 Met1-Gly198.
Storage: Antibody can also be aliquotted and stored frozen at -20° C to -70° C in a manual defrost freezer for six months without detectable loss of activity. The antibody can be stored at 2° - 8° C for 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ug$365.00Add to Cart

ZIC1 or Zinc finger protein ZIC 1 is a member of the ZIC family of C2H2-type zinc finger proteins. These proteins are particularly important during embryonic development. ZIC1 is a transcriptional activator via interaction with GLI1, GLI2, and GLI3. ZIC1 facilitates development and maturation of the cerebellum and spinal cord during organogenesis of the CNS. Within the pontine gray nucleus (PGN) ZIC1 plays a role in spatial distribution of mossy fiber neurons. The interaction between Zic and Gli family proteins are significant for molecular antagonistic and synergistic factors in development.

This protein is mainly found within the CNS and has high levels of expression in the cerebellum. In cancerous tissue, the ZIC1 protein is often found in medulloblastomas. ZIC1 has been used as a neuroepithelial marker.

Images