Chemokine receptors are seven-transmembrane domain G-protein coupled receptors that mediate the biological activities of chemokines. Most of these receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. They are named according to the chemokine subfamily they bind. There are currently six CXC-specific receptors designated CXCR1 to CXCR6, eleven CC-specific receptors designated CCR1 to CCR11, and one C receptor, XCR1. CX3CR1 is the receptor for fractalkine.
Image: CXCR4 staining of human peripheral blood mononuclear cells using rhodamine red Xconjugated antimouse secondary antibody. Cells are counterstained with Fluoro Nissl (green).
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- Raphael Jorand, Sunetra Biswas1, Devin L. Wakefield, Steven J. Tobin, Ottavia Golfetto, Kelsey Hilton, Michelle Ko, Joe W. Ramos, Alexander R. Small, Peiguo Chu, Gagandeep Singh, and Tijana Jovanovic-Talisman. (2016). Molecular signatures of mu opioid receptor and somatostatin receptor 2 in pancreatic cancer. Mol. Biol. Cell, doi: 10.1091/mbc.E16-06-0427
- Hojjat Naderi-Meshkin, Maryam M. Matin, Asieh Heirani-Tabasi1, Mahdi Mirahmadi, Muhammad Irfan-Maqsood, Mohmmad Amin Edalatmanesh, Mina Shahriyari, Naghmeh Ahmadiankia, Nasser Sanjar Moussavi, Hamid Reza Bidkhori andA hmad Reza Bahrami. (2016). Injectable hydrogel delivery plus preconditioning of mesenchymal stem cells: exploitation of SDF-1/CXCR4 axis towards enhancing the efficacy of stem cells' homing. Cell Biology International, doi: 10.1002/cbin.10474
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