Product Details
Catalog Number: MO15066
Applications: WB, IHC, E, IP
Type: Mouse IgG
Dilutions: IHC 25ug/ml; WB 1-2 ug/mL; E 0.5-1.0 ug/mL
Immunogen: NS0-derived rhBACE-1 ectodomain
Storage: Antibody can be aliquotted and stored frozen at -20° C to -70° C in a manual defrost freezer for six months without detectable loss of activity. The antibody can be stored at 2°- 8° C for 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human, Mouse
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ug$205.00$89.00Add to Cart
500 ug$325.00Add to Cart

Cleavage of amyloid precursor protein (APP) into 40 or 42 amino acid amyloid β (aβ) peptides is a result of the action of two proteases β- and γ-secretase. The beta-site APP cleaving enzyme, or BACE-1, is a transmembrane aspartic protease that is localized in the golgi and endosomes. Low levels of BACE-1 mRNA are found in most adult tissues with a higher level of expression in pancreas.

It is important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. 

Image: Detection of BACE-1 in human cerebellum. Stained with HRP-DAP (brown) and counter-stained with hemtoxylin (blue).