Product Details
Catalog Number: MO15074
Applications: WB, IHC
Type: Mouse IgG
Immunogen: Hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, insect cell line Sf 21-derived, recombinant human insulin-like growth factor I receptor (rhIGF-I R) extracellular domain.
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ug$155.00Add to Cart
500 ug$325.00Add to Cart

IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The alpha subunit of IGF-I receptor is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues.

Images

1. Lysates prepared from NTERA-2 , SK-MEL-28 , & G-361 cells in non-reducing sample buffer. Lysates were resolved by SDS-PAGE & transferred to an Immobilon-P membrane. Blot was developed with 1 μg/mL IGF-I R antibody and WesternGlo Chemiluminescent Detection Substrate. 2. IGF-I R (dilution: 25 µg/mL) staining of paraffin-embedded human skin tissue, and stained with anti-mouse HRP-DAB (BN) & counterstained with haematoxylin (BL).

1. Lysates prepared from NTERA-2 , SK-MEL-28 , & G-361 cells in non-reducing sample buffer. Lysates were resolved by SDS-PAGE & transferred to an Immobilon-P membrane. Blot was developed with 1 μg/mL IGF-I R antibody and WesternGlo Chemiluminescent Detection Substrate. 2. IGF-I R (dilution: 25 µg/mL) staining of paraffin-embedded human skin tissue, and stained with anti-mouse HRP-DAB (BN) & counterstained with haematoxylin (BL).