The mammalian serine protease Omi (also known as HtrA2), was identified as a 49 kDa serine protease, homologous to the bacterial endoprotease HtrA (high-temperature requirement). It is a homotrimeric serine protease that localizes to the mitochondria and is processed to expose an N-terminal reaper-like motif similar to SMAC/Diablo. Omi/HTRA2 is released from the mitochondria in response to apoptotic insult and can interact with the BIR2 or BIR3 domains of XIAP to relieve caspase-IAP inhibition.
It is suspected to play a role in Parkinson's, Alzheimer's, Diabetes and certain forms of cancer.
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