"We recently ordered your BMP7 antibody, and I used it on rat spinal cord sections. It worked beautifully." Molly Fuller (Dr. Robert Miller Lab), Case Western University.
BMP-7, or osteogenic protein 1 (OP-1), is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor β (TGF-β) superfamily. BMPs regulate cartilage and bone formation, embryogenesis and morphogenesis of various tissues and organs, and growth, differentiation, chemotaxis and apoptosis of various cell types. Biologically active BMP-7 is a disulfide-linked homodimer. Cellular responses to BMP-7 have been shown to be mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors.
Image: BMP7 in paraffin-embedded human prostate cancer tissue. HRP-DAB reagents (brown color) were used for the detection. Tissue sections were counterstained using hematoxylin (blue).
BMP-7: Customer Publication