Product Details
Catalog Number: MO15081
Applications: WB, FC
Type: Mouse IgG
Immunogen: Hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, Sf21-derived, recombinant human insulysin/insulin degrading enzyme (rhIDE; Accession # NP_004960, aa 42 – 1019). Clone#: 334501.
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Primate
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$235.00Add to Cart

Insulysin, a wide expressed protein,  is responsible for the degradation of insulin in cells. Primarily located in the cytosol,  insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B-chain, glucagon, denatured hemoglobin, alpha-amyloid protein, TGF-alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer's disease research.

Figure: HeLa cells were stained with anti-Insulysin (filled histogram) or isotype control (open histogram) followed by APC-conjugated rat antibody

 

Other Reagents to Consider:

Insulysin/IDE-Goat

Insulin

Matrix Metalloproteinases (MMPs)

Beta-Amyloid (1-40)

Beta-Amyloid (1-42)

 

All Diabetes and Obesity Antibodies

All Neurodegenerative Disease Antibodies

 

Images