Product Details
Catalog Number: MO15082
Applications: WB, E
Type: Mouse IgG
Immunogen: Hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, NS0-derived, recombinant Serpin A3 (rhSerpin A3; aa 26 - 423)- Clone: 213907.
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human
Downloads: Datasheet (pdf)
Product Sizes
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500 ug$325.00Add to Cart

The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Serpin A3, also called α1-Antichymotrypsin, is a major constituent of the plaques associated with Alzheimer’s disease. Deficiency in Serpin A3 activity is associated with chronic obstructive pulmonary disease.

 

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