Somatostatin Receptor 2 (SSTR2) is one of five 7-transmembrane G-protein-coupled receptors for somatostatins 14 and 28. Human SSTR2 shares 84% aa identity with mouse SSTR2 within the extracellular domains. Isoform B (357 aa) has an alternate C-terminal cytoplasmic region that is 12 aa shorter than that of isoform A (369 aa, reported as 93 kDa). Both are expressed in brain, stomach, intestinal epithelia, pancreatic islets and kidney tubules. Isoform B is also expressed in parotid, thyroid and bronchial glands.
These SST Receptors function in the regulation of numerous phsiological processes such as the secretion of insulin, glucagon and growth hormone as well as cell growth induced by neuronal excitation in both the central and peripheral nervous systems.
Image: MDA-MB-231 cells were stained with anti-SSTR2 (filled histogram) or isotype control antibody (open histogram), followed by APC-conjugated anti-mouse antibody.
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Name Catalog # Frizzled 4/CD344 GT15217 Vasopressin V1B Receptor GT41005 Corticotropin Releasing Hormone Receptor 1 GT41006 Vasopressin V1B Receptor GT41021 APJ (Apelin Receptor) MO15011 Rhodopsin (B630) MO22127 Rhodopsin (A531) MO22128 Orphanin FQ/Nociceptin RA10106 Alpha 2a Adrenergic Receptor RA14110 Bradykinin Receptor B2 RA14137 Alpha 2c Adrenergic Receptor RA19064 Oxytocin RA24604 Somatostatin Receptor-1-SSTR1 RA25004 Somatostatin Receptor-2-SSTR2 RA25005 GPR49 RA25071 Frizzled 7 RA30031 Frizzled 9 RA30032 GPR3 RA30048 GPRC6A RA30049 GPR12 RA30050