Somatostatin Receptor 2 (SSTR2) is one of five 7-transmembrane G-protein-coupled receptors for somatostatins 14 and 28. Human SSTR2 shares 84% aa identity with mouse SSTR2 within the extracellular domains. Isoform B (357 aa) has an alternate C-terminal cytoplasmic region that is 12 aa shorter than that of isoform A (369 aa, reported as 93 kDa). Both are expressed in brain, stomach, intestinal epithelia, pancreatic islets and kidney tubules. Isoform B is also expressed in parotid, thyroid and bronchial glands.
These SST Receptors function in the regulation of numerous phsiological processes such as the secretion of insulin, glucagon and growth hormone as well as cell growth induced by neuronal excitation in both the central and peripheral nervous systems.
Image: MDA-MB-231 cells were stained with anti-SSTR2 (filled histogram) or isotype control antibody (open histogram), followed by APC-conjugated anti-mouse antibody.
Other Reagents to Consider:
|Vasopressin V1B Receptor||GT41005|
|Corticotropin Releasing Hormone Receptor 1||GT41006|
|Vasopressin V1B Receptor||GT41021|
|APJ (Apelin Receptor)||MO15011|
|Alpha 2a Adrenergic Receptor||RA14110|
|Bradykinin Receptor B2||RA14137|
|Alpha 2c Adrenergic Receptor||RA19064|