Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T cells. It is the prototype member of the IL-17 family that also includes IL-17B, C, D, E, and F.
IT exhibits multiple biological activities on a variety of cells including: the induction of IL6, IL8 and GCSF production in fibroblasts; the enhancement of surface expression of ICAM 1 in fibroblasts; activation of NF kappaB and costimulation of T cell proliferation. IL17 is an approximately 16 kDa polypeptide of 136 amino acids. The precursor form of IL17 consists of 155 amino acids. To generate the mature IL17 (136 amino acids), the precursor cleaves a 19 amino acid signal peptide. Human IL17 shows approximately 62.5% amino acid homology to mouse IL17 and 58% amino acid homology to rat IL17.
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Name Catalog # Size CXCL8/IL-8 GT15156 100 ug Fractalkine(CX3CL1) GT15024 100 ug IL-1 alpha/IL-F1 GT15101 100 ug IL-1 beta (Mouse) GT15102 100 ug IL-1 beta (Rat) GT15105 100 ug IL-17E/IL-25 MO15111 500 ug IL-2 MO15069 100 ug IL-2 MO15069 500 ug IL-2 (Rat) GT15155 100 ug IL-4 MO15071 100 ug IL-4 MO15071 500 ug IL-6 (Mouse) GT15103 100 ug IL-6 (Rat) GT15106 100 ug Macrophage Inflammatory Protein 1alpha (MIP-1a)/CCL3 GT15070 100 ug Macrophage Inflammatory Protein 1alpha (MIP-1a)/CCL3 GT15070 50 ug Macrophage Inflammatory Protein 1beta (MIP-1beta)/CCL4 GT15071 100 ug TNF alpha GT15113 100 ug