Cathepsin G expression in normal tissues is restricted to granulocytes, especially neutrophils. However, mononuclear phagocytes have been demonstrated to bind and internalize proteases from neutrophils. Cathepsin G is located in neutrophilic polymorphonuclear leukocytes which contain specialized azurophil granules together with two other serine proteases; elastase and hepsin. These three proteases may participate in the killing and digestion of engulfed pathogens and in connective tissue remodelling at sites of inflammation. Cathepsin G is also reported to be expressed in acute and chronic myeloid leukemias whereas acute lymphoblastic or chronic lymphocytic leukemias are negative for this protein.
Image: Cathepsin G staining of Human Tonsil. Note intense membrane staining of polymorphonuclear leukocytes. Paraffin section.
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Name Catalog # Cathepsin D GT15042 Caspase-3 GT15044 Caspase-9 GT15045 Cathepsin B (Human) GT15046 Cathepsin B (Mouse) GT15047 Cathepsin L (Human) GT15048 Cathepsin L (Mouse) GT15049 Cathepsin O GT15197 Cathepsin S GT15198 Cathepsin V GT15199 Cathepsin F MO15096 Caspase-7 MO25036 Caspase-3, active RA15046 Caspase-10/b-Flice 2 RA15047 Caspase-12 RA15048 Caspase-14 RA30061 CARD8 RA30062 CARD9 RA30063