Product Details
Catalog Number: MO20021
Applications: WB, IHC
Type: Mouse IgG
Immunogen: Prokaryotic recombinant protein corresponding to a 124 amino acid N-terminal region of the cathepsin G molecule.
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human
Downloads: Datasheet (pdf)
Downloads: SDS (pdf)
Product Sizes
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100 ul$125.00Add to Cart

Cathepsin G expression in normal tissues is restricted to granulocytes, especially neutrophils. However, mononuclear phagocytes have been demonstrated to bind and internalize proteases from neutrophils. Cathepsin G is located in neutrophilic polymorphonuclear leukocytes which contain specialized azurophil granules together with two other serine proteases; elastase and hepsin. These three proteases may participate in the killing and digestion of engulfed pathogens and in connective tissue remodelling at sites of inflammation. Cathepsin G is also reported to be expressed in acute and chronic myeloid leukemias whereas acute lymphoblastic or chronic lymphocytic leukemias are negative for this protein.

Image: Cathepsin G staining of Human Tonsil. Note intense membrane staining of polymorphonuclear leukocytes. Paraffin section.