Product Details
Catalog Number: MO50000
Applications: WB, IHC, IP, IF
Type: Mouse IgG
Immunogen: Fusion protein amino acids 77-299 of human PSD-95/SAP90 (accession number P78352).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 1742
UniProt: P78352
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ul$405.00Add to Cart

PSD-95 or SAP90 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons,[1] and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels. PSD-95 is a excellent marker for post synpatic mechanisms.

Note: This antibody has been developed by UC Davis under a grant by NIH.

Reference: 
Hunt CA, Schenker LJ, Kennedy MB (Feb 1996). "PSD-95 is associated with the postsynaptic density and not with the presynaptic membrane at forebrain synapses.". Journal of Neuroscience 16 (4): 1380–1388. PMID 8778289. 

Images

PSD-95 (green) and Kv4.2 (red) staining of rat hippocampal neurons.

PSD-95 (green) and Kv4.2 (red) staining of rat hippocampal neurons.

PSD-95 western blots of adult rat brain membranes (RBM), and adult mouse hippocampal membranes (MHM) from PSD-95 knockout and WT mice (mouse samples courtesy of Dr. Richard Huganir).

PSD-95 western blots of adult rat brain membranes (RBM), and adult mouse hippocampal membranes (MHM) from PSD-95 knockout and WT mice (mouse samples courtesy of Dr. Richard Huganir).

PSD-95 western blots of adult rat brain membranes (RBM), and adult mouse hippocampal membranes (MHM) from PSD-95 knockout and WT mice (mouse samples courtesy of Dr. Richard Huganir).

PSD-95 western blots of adult rat brain membranes (RBM), and adult mouse hippocampal membranes (MHM) from PSD-95 knockout and WT mice (mouse samples courtesy of Dr. Richard Huganir).