Neuromics loves when our customers utilize our products in their publications. One publication investigates the role of CtBP2 in cortical development in mammals. Using our Nestin (Cat.# GT15114) antibody, they find that CtBP2 is key in the maintenance and migration of neural stem and progenitor cells during cortical development in mice. Through this research, CtBP2's role in neurological development is better understood.
Image: Representative confocal images of developing cortex of C57BL/6 mice, immunostained against Nestin antibody. Yellow boxes indicate magnified region of the cortex represented in the lower left corner of each image. Image courtesy of Esra Karaca, et al. (2020). The Corepressor CtBP2 is Required for Proper Development of the Mouse Cerebral Cortex. Molecular and Cellular Neuroscience. doi: 10.1016/j.mcn.2020.103481
Learn more about another recent publication...
This new publication, uses our Tuj1 (Cat.# MO15013) antibody to explore the impact of variants in the TMEM106B gene. By knocking-out the gene in mice, they find that LAMP1-positive vacuoles are enlarged in proximal axon of motorneuron nuclei. Their evidence links the TMEM106B gene to neurological disorders.
Image: Representative confocal images of the axon of lentivirus-infected tandem fluorescent-tagged LC3-expressing primary MNs of Tmem106bKO and control cells. RFP channel is depicted in red, GFP channel is depicted in green. The axon is stained with an antibody against Tuj1 (blue). Image courtesy of Patrick Luningschror, et al. The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons. Cell Reports, 30(10), 3506-3519. doi: 10.1016/j.celrep.2020.02.060