Adenosine Biology and Pancreatic Cancer and Tumor Microenvironment (TME)-https://doi.org/10.1038/s41591-026-04283-z
Researchers from Arcus Biosciences, UCLA, Columbia, Stephenson Cancer Center, MD Anderson Cancer Center, Sarah Cannon Research Institute, University of Wisconsin, and NYU Langone used Neuromics' Pancreatic Cancer-Associated Fibroblasts (CAFS) to conduct a Phase 1 Study.
"Quemliclustat and chemotherapy with or without Zimberelimab in metastatic pancreatic adenocarcinoma: a randomized phase 1 trial." https://doi.org/10.1038/s41591-026-04283-z
Elevated adenosine levels in the TME suppress inflammation and immune function, markedly limiting the ability of the immune system to destroy tumor cells.
Our CAFs have a long history of being utilized to study the TME. A growing trend we're seeing is the use of these cells in 3D models. Our colorectal, pancreatic, breast, and ovarian CAFs have all been used in 3D TME models in recent publications.
We have a large selection of CAFs, including around a dozen types of normal CAFs and several hTERT immortalized CAFs. Check them all out below.