GDF-5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
Image: GDF-5 protein structure and sequence
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size BMP-2 PR15013 10 ug BMP-2 PR27023-10 10 ug BMP-2 PR27023-2 2 ug BMP-2 (E. coli-expressed), CF PR15014CF 10 ug BMP-2 (E.coli-expressed) PR15014 10 ug BMP-2, CF PR15013CF 10 ug BMP-4 PR15015 10 ug BMP-4 PR27024-10 10 ug BMP-4 PR27024-2 2 ug BMP-4, CF PR15015CF 10 ug BMP-7 PR27026-10 10 ug BMP-7 PR27026-2 2 ug BMP-7 CHO PR27001-10 10 ug BMP-7 CHO PR27001-2 2 ug GDF-5 PR27028-10 10 ug Noggin PR27117-20 20 ug Noggin PR27117-5 5 ug Noggin/Fc Chimera, Carrier Free PR15070CF-50 50 ug OPG PR27029 10 ug OPG PR27029-50 50 ug Pleiotrophin/OSF-1 PR27119-20 20 ug Pleiotrophin/OSF-1 PR27119-5 5 ug