Product Details
Catalog Number: RA15002
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding T202/Y204 of human, rat and mouse extracellular signal-regulated kinase-1 (ERK1), alternatively known as mitogen-activated protein kinase-3 (MAPK3) and p44 MAPK. This sequence also matches residues surrounding T185/Y187 of ERK2, also called MAPK1 and p42 MAP.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$325.00Add to Cart

ERK1 and ERK2 (also known as MAPK3 and MAPK1) are 44- and 42-kDa Ser/Thr kinases, respectively. They are part of the Ras-Raf-ERK signal transduction cascade often found downstream of growth factor receptor activation. ERK1 and ERK2 were initially isolated and cloned as kinases activated in response to insulin and NGF. They are expressed in most, if not all, mammalian tissues. Dual threonine and tyrosine phosphorylation activate both ERKs, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2.