Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).
Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.
Image: Caspase 10/b Immunoblotting of SDS-extracts from 2 x 105 human Jurkat cells. Extracts were electrophoresed on 20% gels and dilution was with 1.0 mg/mL
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Name Catalog # Cathepsin D GT15042 Caspase-3 GT15044 Caspase-9 GT15045 Cathepsin B (Human) GT15046 Cathepsin B (Mouse) GT15047 Cathepsin L (Human) GT15048 Cathepsin L (Mouse) GT15049 Cathepsin O GT15197 Cathepsin S GT15198 Cathepsin V GT15199 Cathepsin F MO15096 Cathepsin G MO20021 Caspase-7 MO25036 Caspase-3, active RA15046 Caspase-12 RA15048 Caspase-14 RA30061 CARD8 RA30062 CARD9 RA30063