Product Details
Catalog Number: RA15047
Applications: WB
Type: Rabbit IgG
Immunogen: KLH coupled synthetic peptide: KRTVWGAKQISATSLPTA(C) corresponding to amino acids 487 - 504 of human
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse
Downloads: Datasheet (pdf)
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100 ug$275.00Add to Cart

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Image: Caspase 10/b Immunoblotting of SDS-extracts from 2 x 105 human Jurkat cells. Extracts were electrophoresed on 20% gels and dilution was with 1.0 mg/mL

Other Reagents to Consider:

Antibodies:

Caspase-2

Caspase-3

Caspase-3, active

Caspase-7

Caspase-9

Caspase-10b

Caspase-12

Bcl-2

Apoptosis Antibodies

Caspases and Cathepsins

Cancer Antibodies

Neurodegenerative Disease

Proteins

Bcl-2

All Apoptosis Reagents

Stem Cell Reagents

Images