Catalog Number: RA18006
Type: Rabbit IgG
Immunogen: amino-terminal region of human CaMKII
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Primate
CaMKII (Calcium/calmodulin-dependent protein kinase II) is a ubiquitous serine/threonine protein kinase that is abundant in the brain as a major constituent of the postsynaptic density (PSD). The enzyme is an oligomeric protein composed of distinct but related subunits, alpha, beta, gamma, and delta, each encoded by a separate gene. CAMK2A assembles into heterooligomeric complexes with other CAMK2 subunits.
CaMKII is a prominent kinase in the central nervous system that may function in long term potentiation and neurotransmitter release. It plays a role in immune response and inflammatory pain.
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- Haifeng Zhaoa, Qiong Li, Xinrong Pei, Zhaofeng Zhang, Ruiyue Yang, Junbo Wang and Yong Li. (2009). Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus. Behavioural Brain Research, Volume 201, Issue 2, 12 August 2009, Pages 311-317. doi: 10.1016/j.bbr.2009.03.002.
- Q. Li, H.F. Zhao, Z.F. Zhang, Z.G. Liu, X.R. Pei, J.B. Wang, M.Y. Cai and Y. Li. (2009). Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding protein signaling cascade. Neuroscience, doi: 10.1016/j.neuroscience.2009.02.008
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